منابع مشابه
Utility of Cationic and Anionic Chiral Surfactants in Capillary Electrophoresis (CE) and CE Coupled to Mass Spectrometry (CE-MS)
The research presented in this thesis involves the application of chiral cationic and anionic surfactants for simultaneous enantioseparation of structurally similar compounds in capillary electrophoresis (CE) and CE coupled to mass spectrometry (CE-MS). The first chapter briefly introduces the fundamentals of CE and CE-MS, emphasizing the micellar electrokinetic chromatography (MEKC) and MEKC-M...
متن کاملDetermination of Benzodiazepines in Urine by CE-MS/MS
Using capillary electrophoresis combined with tandem mass spectrometry, we have developed a method to simultaneously detect lorazepam, clonazepam, temazepam, oxazepam, diazepam, and nitrazepam in urine. The urine samples were submitted to a modified QuEChERS extraction procedure, followed by electrophoretic separation in 0.1 M formic acid electrolyte (pH 2.4) using a polyvinyl alcohol (PVA)-coa...
متن کاملSheathless CE-MS and comparison with nanoRP-
22 Purification and quality control of therapeutic peptides is often performed by one single method, RP23 HPLC. As usage of an orthogonal technique is highly advisable for quality assurance, capillary 24 electrophoresis (CE) employing a coated capillary coupled via a sheathless interface to a mass 25 spectrometer was applied in parallel. The basic therapeutic peptide aviptadil served as a model...
متن کاملChiral CE separation of dopamine-derived neurotoxins.
An enantiomeric separation of dopamine-derived neurotoxins by capillary electrophoresis has been developed. Tetrahydroisoquinoline (TIQ), dopamine (DA), (R/S)-1-benzyl-TIQ (BTIQ), (R/S)-6,7-dihydroxy-1-methyl-TIQ (salsolinol, Sal), and (R/S)-6,7-dihydroxy-1, 2-dimethyl-TIQ (N-methyl-salsolinol, NMSal) were studied as model compounds. The CE running buffer (50 mM phosphate buffer at pH 3.0) cont...
متن کاملSensitive chiral analysis by CE: an update.
A general view of the different strategies used in the last years to enhance the detection sensitivity in chiral analysis by CE is provided in this article. With this purpose and in order to update the previous review by García-Ruiz et al., the articles appeared on this subject from January 2005 to March 2007 are considered. Three were the main strategies employed to increase the detection sens...
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ژورنال
عنوان ژورنال: ELECTROPHORESIS
سال: 2010
ISSN: 0173-0835,1522-2683
DOI: 10.1002/elps.200900673